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Specifically, sermorelin is the smallest GHRH fragment and possesses the bioactive sequence responsible for evoking the secretion of growth hormone (GH) from the anterior pituitary gland [1, 2]

Ipamorelin is a synthetic peptide that mimics the action of ghrelin, a hormone involved in growth hormone release

This selectivity makes it a valuable research tool for investigating GHS-R1a-mediated signaling pathways, receptor activation kinetics, and ligand-receptor interactions without the broader receptor activity observed with less selective secretagogues

However, the precise molecular details require further experimental clarification