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29 Progressively several other nanomedicines were reported as potential candidates for RA therapy like MTX combined with nanoemulsions, 30 siRNA-loaded chitosan nanoparticles, 31 curcumin-loaded carboxy methyl cellulose acetate (CMCAB), 32 exosomes as biomimetic particles, 33 stimuli-responsive liposomes, 34 MTX and siRNA loaded carbon nanotubes, 35 poly(amidoamine) (PAMAM) dendrimers functionalized with chondroitin sulphate and with anti-TNF- to provide anti-inflammatory properties 36 and mesoporous silica nanoparticles encapsulating dexamethasone 37 to deliver the traditional drugs

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Then, six sections were obtained for each guinea pig tissue and placed onto positively charged slides

doi: 10.1038/nature23007