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For example, in the case of phosphinic pseudopeptide inhibitors, which mimic the transition state of peptide substrates, Tyr549 changes orientation upon ligand binding to interact with one of the oxygen atoms of the phosphinic group, which is equivalent to the oxygen atoms of the substrate in the transition state

DOT-regulated positions Department of Transportation regulations mandate drug testing for safety-sensitive positions including truck drivers, pilots, railroad workers, and public transit operators