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Moreover, these proteins may misfold, further impair proteasomal and autophagic pathways

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Jun 14 2021;14(6)doi:10.3390/ph14060569 Pasquariello R, Verdile N, Brevini TAL, et al

Additionally, elevated levels of the plasma amino acid homocysteine can be a functional marker of folate, vitamin B12, or vitamin B6 deficiency, as all these vitamins are required to convert homocysteine into methionine