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The Population Pharmacokinetics of Allopurinol and Oxypurinol in Patients with Gout

Peripheral cytokines reach the brain through different non-exclusive mechanisms, including bloodbrain barrier (BBB) disruption 62 , penetration of peripheral immune cells, and via afferent nerve fibers, such as the vagus nerve, a bundle of parasympathetic sensory fibers that conveys information from peripheral organs to the CNS 63