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31 Healthy endothelial cells regulate vascular tone in response to a complex network of signals by modulating their production of eNOS

Evidence also indicated a direct association between phases of migraine attacks and calcitonin gene-related peptide (CGRP), mitochondrial disorders, monoaminergic pathway, disruption in brain energy metabolism, and higher serum levels of glutamate and homocysteine

Epithelial tight junction is a critical intestinal barrier, and its disruption could leak toxic substances from the gut into blood circulation and cause systemic injury

Lifestyle modifications include changes in diet, an increase in physical activity, and smoking cessation