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Preclinical studies have elucidated multiple direct anti-atherogenic mechanisms of GLP-1 RAs, including suppression of pro-inflammatory cytokine production (TNF-, IL-1, IL-6) in macrophages, inhibition of monocyte adhesion to endothelial cells through downregulation of adhesion molecules, reduction of oxidized LDL-induced foam cell formation, and attenuation of atherosclerotic plaque development in murine models ( SGLT2i also demonstrate anti-atherosclerotic effects

Inhibiting this pathway leads to enhanced fat metabolism and improved glucose tolerance. Hong et al., Nature Medicine Biohackers and Longevity Enthusiasts Because it increases NAD a key coenzyme in energy metabolism, DNA repair, and aging 5-Amino-1MQ may appeal to those looking to extend healthspan, improve cellular resilience, and combat age-related decline

Animal experiment design Eight-week-old male C57BL/6 mice were procured from the Dashuo Experimental Animal Center (Chengdu, China)

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