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Preclinical therapies to prevent or treat fracture non-union: a systematic review

Besides, IH could promote neuronal apoptosis in normal mice and diabetes mice models, the latter had higher apoptosis levels and could be modulated by high mobility group box-1 protein (HMGB1)/toll-like receptor 4 (TLR4) signal [53]

These findings indicate that limiting serine metabolism may have significant implications for immunotherapy, highlighting the importance of targeting these pathways in cancer therapy