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30- , ,

esculetin, have been shown to regulate activation of JNK and AMPK in liver injury and to exhibit hepatoprotective effects

The manuscript highlights how DDSsincluding stimuli-responsive nanoparticles, targeted ligands, and biodegradable carriersenhance solubility, bioavailability, and tissue-specific delivery of urate-lowering agents (e.g., allopurinol and febuxostat) and anti-inflammatory therapies (e.g., colchicine and IL-1 inhibitors) (Liu S