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doi: 10.1074/jbc.272.48.30371

doi:10.1007/s40200-022-01165-2 [PubMed][CrossRef] 137

Furthermore, CHAC1 negatively regulates the NOTCH1 receptor, a key player in determining cell fate, particularly in neuronal stem cells, affecting their development and differentiation ( 2.1 CHAC1 upregulation under arsenite stress and amino acid depletion As a stress-responsive protein, CHAC1 is critically involved in the cellular stress response

We discussed the research behind the FDAs announcement with Margaret McCarthy, PhD, an NAM member and neuroscientist studying early brain development at the University of Maryland