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Numerous studies also proved that ER stress contributes to intestinal inflammation diseases via the activation of IRE1/ATF6-XBP1 signaling pathway (1214)

Interestingly, MGMT is a DNA repair enzyme responsible for demethylating O6-methylguanine in normal cells, which repairs the O6-alkylguanine lesions in DNA by transferring the alkyl groups from the O6-position of guanine to its own active center Cys145 residue and restores normal DNA

It has been evident that CD44 as a surface biomarker of cancer stem cells (CSCs) and a vital regulatory factor of epithelial-mesenchymal transition (EMT) program is involved in the regulation of tumor initiation and development [6, 15,16,17]

High-dose corticosteroids in patients with the adult respiratory distress syndrome