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Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise

This original work has not been published previously nor is it under consideration elsewhere

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This phenomenon has been documented in the brain and spinal cord dorsal horn, representing a molecular model for pain potentiation via NMDA directed intranuclear modification