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Since microtubules play an important role in maintaining cell morphology, establishing cell polarity, and intracellular information transmission, hyperphosphorylated Tau protein could result in the loss of affinity with microtubules and lead to microtubules unstable and disintegrated, which in turn affects the transport and morphological structure of nerve cells, leading to the death of nerve cells [38, 39]

1.2 Targeting autophagy for cancer therapy Autophagy, a critical mechanism for maintaining cellular balance by removing damaged organelles and protein aggregates, can also facilitate cell death (Liu et al., 2023)

It is essential to follow a doctors advice and follow the treatment plan they recommend

462 The most advanced application of POCs is the delivery of charge-neutral oligonucleotides, such as PNA and PMO, using CPPs