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Inhibiting TGF- could reduce fibrosis but may interfere with its protective roles in resolving inflammation and promoting tissue repair, leading to unintended consequences.93 94 Therefore, therapeutic approaches targeting TGF- must be carefully considered and finely tuned to balance its profibrotic and anti-inflammatory effects

ESHRE guideline: management of women with premature ovarian insufficiency [J]

Metformin is typically administered orally, in the form of tablets or capsules

When external stimuli excite the vagus nerve, the nerve terminals produce the anti-inflammatory parasympathetic neurotransmitter acetylcholine (ACh), which activates the 7 nicotinic acetylcholine receptors (7nAChR) on monocytes and macrophages