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Some patients see changes earlier

For one, we used the MitoQC mouse, an animal enabling strong, direct in vivo evidence of mitophagymitochondria have green and red fluorescence that turns to red fluorescence alone when the mitochondrion is engulfed in a lysosome (McWilliams et al., 2016)

This natural reduction in collagen affects not only our physical appearance, such as decreased skin elasticity, but also the functional integrity of our joints and muscles

-------------------------------------------------------------------------------- 1 Based on a maximum recommended amitriptyline dose of 150 mg/day or 3 mg/kg/day for a 50 kg patient