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Increased pain threshold They can present with one or more of the above-listed physical symptoms, along with a description of flu-like symptoms that include (85)(86): A runny nose (rhinorrhea) Excessive sweating (Diaphoresis) Excessive itching (pruritus) Gastrointestinal complaints (nausea, diarrhea) Beginning behaviors associated with Opioid Use Disorder (OUD) appear through changes in the way that the person acts