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Many studies have indicated that tumor tissue is a constantly evolving ecosystem contained a wide variety of cells with different phenotypes and mutations, such as cancer cells, tumor-associated fibroblasts, immune cells, cells related to blood vessels and so on, the gene mutations and epigenetic regulation of which caused by WM treatment could synergistically promote drug resistance and immune escape of cancer cells by rebuilding tumor microenvironment (TME)

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Furthermore, PKA and PKC can phosphorylate some of the same downstream targets, leading to an amplified signal for both GH release and synthesis