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Annu Rev Pharmacol Toxicol 45:5188

Additionally, DOX diminished the expression of brain-derived neurotrophic factor (BDNF) and increased phosphoinositol-3-kinase (PI3K), phosphorylated-Akt (pAkt), and mammalian target of rapamycin (mTOR) content

No long-term safety registry exists for repeated glutathione exposure in non-clinical populations, and interactions with medications are not fully characterized