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Locke JA, Guns ES, Lehman ML, Ettinger S, Zoubeidi A, Lubik A, et al

365 Moreover, activated P-selectin on the surface of platelets in patients with SLE binds to P-selectin glycoprotein ligand-1 modified with CD15s on Tregs, leading to the upregulation of spleen tyrosine kinase-dependent calcium signaling and the inhibition of the TGF- pathway, thereby impairing Treg function

The increase in circulating aldosterone stimulates renal K + secretion which restores the serum K + concentration to normal without affecting renal Na + retention 6,10