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A pharmaceutical formulation comprising: an effective amount of cagrilintide and semaglutide, more than 10% w/v and less than 22% w/v, such as 10-20% w/v cyclodextrin of the hydroxypropyl-substituted alpha and/or beta type, said cyclodextrin comprising a minimum of about 0.4 and a maximum of about 1.0 hydroxypropyls per glucose unit, such as 0.58-1 .0 hydroxypropyls per glucose unit, about 3-30 mM histidine, about 10-40 mg/ml sorbitol, up to 2.0 mg/ml, such as up to 1 .5 mg/ml polysorbate 20 and/or 80, about 75-90% w/w water and having a pH of 5.6-6.0

Results As shown in Table 2 the mean of age of the fertile group (33.4 4.4 years) was decreased when compared to asthenozoospermics (34.9 4.2 years), oligozoospermics (40.2 4.5 years) and teratozoospermics (39 5 years), but the difference was not significant

Pagano C, Navarra G, Coppola L, Avilia G, Bifulco M, Laezza C