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Second, the functional significance of mtDNA methylation remains to be fully defined: whether it primarily modulates mitochondrial gene expression or acts predominantly as a protective mechanism against ROS-induced damage through altered DNA packaging and TFAM binding is still under active investigation

5-ASA drugs (e.g., mesalamine) have limited efficacy in mild-to-moderate UC and are susceptible to drug resistance

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The calculation of the balance between the levels of antioxidants and prooxidative manifestations (an index of Antioxidant/Pro-oxidant Balance, APB) was accomplished