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Although viral small RNAs with the size of piRNAs (2630 nt) were identified during BmCPV infection of silkworm midgut, these were not considered as true vpiRNAs because of the absence of 1U bias and ping-pong signature (68) and manipulation of expression of Siwi and BmAgo-3 can affect infection levels of RNA viruses (69), the role of the piRNA pathway in antiviral defense remains contentious in Lepidoptera and may involve PIWI proteins but not always piRNAs (69) (see section 5 for additional discussion)

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In bacterial bronchopneumonia, combined nebulization with ipratropium bromide and budesonide can shorten symptom relief time and improve pulmonary function indices [43]