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The patients were divided into two groups: those at risk for cardiovascular disease because of a glucose disposal rate less than or equal to 7.9 milligrams per kilogram of bodyweight (16 patients) and those with a glucose disposal rate greater than 7.9 mg/kg/bw (16 patients)

Western blot analysis further demonstrated that diabetes increased the expression of collagen I, a protein associated with renal fibrosis, while treatment with TSWN or valsartan inhibited its expression in diabetic mice ( Figure 2C )

doi: 10.1007/s004280050120 144 WangJ-CLaiSGuoXZhangXde CrombruggheBSonnylalSet al