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While serotonins exact role in depression is still being debated, low serotonin levels have traditionally been linked to symptoms such as sadness, low energy, and irritability all of which are often seen in people with major depressive disorder

The epidemiological data presented in Table 1 sheds light on the prevalence of DPN and painful DPN, and the percentage of undiagnosed DPN and painful DPN among these patients [5, 8, 24,25,26,27,28,29,30,31,32]

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Mice received daily IP injections of D-Nle-Cys-Ile-(6)-amino-hexanoic amide (10 g/kg/day or 100 g/kg/day) or PBS vehicle