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While the mechanisms underlying amyotrophic lateral sclerosis remain elusive, considerable evidence suggests that an overproduction of ROS, coupled with a deficient antioxidant defense system, represents a significant pathological characteristic of the disease (Cunha-Oliveira et al., 2020[105])

Any protocol should be developed in consultation with a qualified healthcare professional

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these reactions generally occur 30-60 minutes after initiating the infusion and resolve despite continued infusion of the drug