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Targeting PI3K-gamma in myeloid driven tumour immune suppression: a systematic review and meta-analysis of the preclinical literature

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10.1007/s12602-023-10167-2 121 VenkateshM.MukherjeeS.WangH.LiH.SunK.BenechetA

Consistently, in relapsed AML/MDS after allo-HCT, high frequencies of CTLA-4/PD-1 and multi-ICMco-expressing T cells and blasts are detectable in uncultured blood and associate with impaired antileukemic activity and poor response to salvage therapy (54)