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Disrupting HDAC4-Ubc9 interactions restores homologous recombination proficiency in hepatocellular carcinoma [72], while targeting USP38-HDAC1 stabilization compromises NHEJ efficiency by suppressing chromatin compaction [6]

However, ccRCC cells contain abundant lipid droplets but do not trigger iron-dependent cell death

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In a clinical study of elderly patients with chronic fatigue, results indicated that most of the subjects treated with Cordyceps sinensis pure mycelium reported a significant clinical improvement in the areas of fatigue, cold intolerance, dizziness, frequent nocturia, tinnitus, hyposexuality, and amnesia, while no improvement was reported in the placebo group [1719]