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The combined quinone redox glutathione metabolism model can be used to simulate experimentally challenging scenarios such as potential redox cycling toxicity, while providing a platform from which quinone exposure and concentration toxicity experiments may be guided

Conclusions Although there is plenty of data on the anabolic potential of GH, IGF-I, and insulin and on their safety and efficacy at physiologic doses, most of this information comes from their therapeutic use in other settings (AGHD, diabetes), or from pathological disorders characterized by hormone hypersecretion (acromegaly, insulinoma)

10.1016/j.freeradbiomed.2018.10.426 116 SongX.LongD

Metallothionein 1 G and zinc sensitize human colorectal cancer cells to chemotherapy