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Oral Bioavailability and Metabolic Stability Many bioactive constituents derived from TCM, particularly glycosides (eg, paeoniflorin, forsythoside A) and alkaloids (eg, berberine), exhibit poor oral bioavailability attributable to limited gastrointestinal stability, efflux transporter involvement, and extensive Phase II metabolism including glucuronidation and sulfation

doi: 10.1002/cmdc.201600538 141 XingWLiuGZhangYZhangTLouHFanP

In the FY 2023 IPPS/LTCH PPS final rule (86 FR 45507), our burden estimates were based on an assumption of approximately 3,150 IPPS hospitals