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doi:10.1080/03007995.2016.1208643

Sebaratnam said one of the main concerns about melanotan was whether it could stimulate pigment cells to become a melanoma - one of the deadliest forms of skin cancer

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In vivo , apigenin reduces the secretion of pro-inflammatory factors (IL-1, IL-6, and TNF-), reduces the expression of the DCs costimulatory molecules CXCR4 and MHCII, and reduces the number of Langerhans cells