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However, despite substantial progress, the precise molecular mechanisms governing ROS perception, signal transduction, and downstream gene regulation remain only partially understood

identified that cGAS-mediated sensing of mtDNA plays a crucial role in the development of lung cancer associated with the genetic loss of Kras and p53

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And finally, further screening of other strains of Lactobacillus and genetic engineering of specific Lactobacillus strains should help in understanding and exploring their broader probiotic therapeutic role