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As the surface characteristics are primarily responsible for the toxicity of the NPs, modification of surface chemistry and properties has been reported to be one of the most common devised strategies to mitigate NP toxicity (Figure 3) ( FIGURE 3 Surface coating is one of the most popular surface modification strategies to reduce the potential toxicity of NPs, which is reversible by non-covalent modification (Hwang et al., 2018)

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But what about the rest

As with all research compounds, investigations should be conducted using proper laboratory practices and established scientific standards