female network oral glutathione Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity: Cell The effects of the – Sex differences in glutathione metabolism

Disclosures: Kezia Hobson: Perspectum Ltd: Employee, Dylan Windell: Perspectum: Employee, asd: Employee, Paul Aljabar: Nothing to Disclose, George Ralli: Nothing to Disclose, Rob Goldin: Nothing to Disclose, Kenneth Fleming: Nothing to Disclose, Caitlin Langford: Nothing to Disclose 775 HISTOLOGICAL DIAGNOSTIC TOOL FOR DETECTING AND CHARACTERISING PORTAL TRACTS IN LIVER DISEASE USING ARTIFICIAL INTELLIGENCE Dylan Windell 1 Alastair Magness 1 Abhishek Roy 1 Paul Aljabar 1 Timothy Kendall 2 Eve Fryer 3 Kenneth Fleming 4 Rob Goldin 5 Caitlin Langford 1 , 1 Perspectum, 2 University of Edinburgh, 3 Oxford University Hospitals NHS, 4 University of Oxford, 5 Imperial College London Background: AI- driven digital workflows for liver biopsy grading and staging have the potential to produce more accurate and reproducible results than traditional assessments

d 5 -JA was added to the extraction solvent (isopropanol: formic acid at 99.5: 0.5, v/v) as internal standard

In the combination therapy with PD-1 blockade, biomarker levels were markedly enhanced compared with monotherapy

Moving toward a systems-level understanding, empowered by interactomics, CRISPR technologies, AI-driven modeling and precision biomarker science, will profoundly transform how we interpret disease biology and develop therapeutics