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However, the proliferative characteristics of the TrxR1-deficient mouse cells that have been studied to date disfavor this model (Mandal et al., 2010

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The experiments show that the problem of Pgp reversal is complex: for example, in cells with 200-fold resistance to vinblastine, verapamil induced twofold decrease of vinblastine resistance, but cross resistance to doxorubicin remained unchanged [36]