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222 Currently, researchers have indicated that the aging process is accompanied by changes in mitochondria, including the increase of mtDNA mutations, changes in mitochondrial metabolism and mitophagy, the breakdown of mitochondrial dynamic balance, etc

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CHIP can promote parkin-mediated ubiquitination of Pael receptor and inhibit the Pael receptor-induced cell death (Imai et al., 2002)

Delphinidin, a potent and abundant anthocyanin found in berries, can activate the NRF2 promoter by promoting its demethylation