Li Y, Song W, Han X, Wang Y, Rao S, Zhang Q, Zhou J, Li J, Liu S, Du G (2022b) Recent progress in key lignocellulosic enzymes: enzyme discovery, molecular modifications, production, and enzymatic biomass saccharification
While the efficacy data did not survive the Phase IIb primary endpoint, the safety dataset across 900 participants is unusual for a research peptide and is consistently cited as the basis for continued investigational interest
A recent animal experiment demonstrated that inulin-type fructans (ITFs) supplementation induced the expansion of acetate-generating bacteria, especially the genera Akkermansia and Candidatus Saccharimonas , and improved renal function, glomerular injury and renal fibrosis in db/db mice (Luo L
TNF-a and IL-6 have, in separate studies, both been identified as potentially key immune factors in ME/CFS The authors go on to note that, in some cases, mental fatigue persists long after the identified neural trauma has been resolved (perhaps due to a genetic predisposition or due to dendritic remodelling) and emphasise the importance of early treatment to prevent the problem becoming chronic : Providing information about mental fatigue, its cause and the prognosis, is of utmost importance for breaking the vicious circle, which comes with the risk for secondary anxiety and depression
