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Description

Journal of Biological Chemistry 293 (37): 1431214327

Amyotrophic Lateral Sclerosis/Riluzole Study Group II

Trimethylamine N-oxide (TMAO), a metabolite derived from gut microbiota, has been shown to correlate with tau pathology, with increased TMAO concentrations observed in the cerebrospinal fluid (CSF) of AD patients, and a positive relationship with NFTs (Vogt et al., 2018)