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Conversely, in diet-induced MASH mice lacking adaptive immunity, adoptive transfer of Treg cells worsened hepatic steatosis and increased serum ALT levels, suggesting a potentially detrimental role in this setting (137)

It is not only a major target for heroin or other opioids, but also for most non-opioid substances of abuse, such as alcohol, cocaine, and nicotine (55, 56)

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Also, immunostaining using an anti-phospho-NF-B p65 antibody demonstrated a significant decrease in phosphorylation of p65 when LPS/ATP stimulated macrophages were pretreated with GYY4137 (Fig