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Their clinical benefits in cardiovascular and renal outcomes have been demonstrated in large randomized trials such as EMPA-REG and CANVAS [11, 12]

doi: 10.1016/j.cell.2016.03.001 237 RajagopalaSVVasheeSOldfieldLMSuzukiYVenterJCTelentiAet al

J Biol Chem (2008) 283(14):883745.10.1074/jbc.M709221200 143 GilquinBTaillebourgECherradiNHubstenbergerAGayOMerleNet alThe AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes