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4 Role of gut microbiota in ferroptosis in critically ill patients The gut microbiota, a complex community of microorganisms residing in the gastrointestinal tract, plays a crucial role in regulating numerous physiological processes, including metabolism, immunity, and oxidative stress ( A key methodological difference must be noted here, most existing studies linking gut microbiota to ferroptosis are based on murine models that can be used to establish causality by experimental interventions such as antibiotic depletion, sterile colonization, and metabolite supplementation