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This peptide is naturally created in the GI system and can be isolated from gastric juices

Compared to glycated BSA (without postbiotics as a negative control), this increase was pronounced in glycated BSA incubated with MSD-37 postbiotics, which used IR methanolic extract as a carbon source for postbiotic production, followed by irilone ( 4 ), then irigenin ( 5 ), and irisolidone ( 3 )

For pathohistological evaluation transversal sections of crushed muscle, longitudinal section of transected muscle and longitudinal section of transected tendon were used

The overexpression of metrnl induces the expression of SIRT3 by promoting the expression of transcriptional activator PGC-1, increasing the expression level of UCP1 and the activation of AMPK in PA-treated RTECs to accelerate mitochondrial autophagy, maintain mitochondrial homeostasis, and alleviate lipid accumulation (a thermogenic factor) (Zhou et al., 2023)