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For instance, homocapsaicin II induces ferroptosis in colorectal cancer cells through a cholesterol centrosome amplification axis, highlighting a novel link between cholesterol metabolism and cellular death pathways (128)

Lifestyle factors amplify or mitigate these effects

Advancing age is characterized by diminished Nrf2 activity, resulting in elevated ROS accumulation and heightened vulnerability to oxidative injury (Bhandari et al., 2021)

Changes in Glutathione Antioxidant Pathway Components, HLA-DR and IgE in Blood from Asthma Patients Treated with Ozone Therapy Abstract We have studied the behavior of the erythrocyte glutathione antioxidant pathway, the HLA-DR molecule expression and the serum IgE level in patients suffering reactive asthma, whose were treated with ozone major autohemotherapy or rectal insufflation