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rocuronium, vecuronium, atracurium, cisatracurium) It is not effective against depolarizing skeletal muscle relaxants (succinylcholine) It may be used adjunctively in the treatment of respiratory depression caused by overdosage of curare like neuromuscular blockers Contraindications: Known hypersensitivity to anticholinesterase agents Intestinal and urinary obstructions of mechanical type Side Effects: The myasthenic patient in crisis who is being tested with edrophonium should be observed for bradycardia or cardiac standstill and cholinergic reactions if an overdose is given

Gardner and Gallagher, 2001

Early Hum

-Denaturing eluents: as a last resort, denaturing eluents such as chaotropic salts may be used to alter the structure of the protein