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Clinical evidence demonstrates that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) effectively decrease urinary albumin excretion rate (UAER) and slow renal function decline, though their nephroprotective benefits prove limited in advanced DN ( SGLT2 inhibitors represent a major breakthrough in DN treatment, demonstrating pleiotropic renoprotective mechanisms beyond glucose-lowering effects (Table 2)

Association between arsenic exposure, DNA damage, and urological cancers incidence: A long-term follow-up study of residents in an arseniasis endemic area of northeastern Taiwan

Intensive Care 10, 145

AOD-9604 acts on adipocyte lipolysis pathways through beta-3 adrenergic receptor signalling, with effects measured at the fat cell level