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In adipose tissue, elevated NNMT activity is strongly correlated with obesity, insulin resistance, and cellular aging

Conservative dosing also reduces risk of excessive energy deficit and the metabolic stress markers (low T3, menstrual irregularity) that emerge when both compounds are pushed to upper dose ranges simultaneously.

In that study, a compensatory induction of keratinocyte lipid-binding protein was observed that was reported to overcome the functional effects of loss of adipocyte-specific aFABP/ALBP/aP2 (110)