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Phytomedicine 71 Motawi TK, El-Maraghy SA, Kamel AS, Said SE, Kortam MA (2023) Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of clemastine in EAE rat model