3d structure of glutathione | C10H17N3O6S | CID 124886 RCSB PDB - 2I3Y: Crystal

Translating animal model results to human outcomes always involves uncertainty

Reported side effects are infrequent and mild: Transient redness or mild swelling at the injection site

Its multi-target mechanisms also indicate therapeutic potential for metabolic, renal, and neurodegenerative disorders

Despite the potential strength of using specific aspartame intake in this analysis, the unclear outcome definition meant that the earlier analysis of NHANES data was considered to be more informative, although both analyses were consistent in not finding strong evidence linking aspartame or ASB intake with cancer mortality.] During a median follow-up of 27.7 years, 135 093 CPS-II participants died from cancer (25.9% of all deaths) (McCullough et al., 2022)