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The major source of ROS comes from non-enzymatic processes in the mitochondrial respiratory chain (22)

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Gamma-glutamylcysteine synthetase deficiency Disease name and synonyms Gamma-glutamylcysteine synthetase deficiency (OMIM #230450) Glutamate-cysteine ligase deficiency Definition and diagnostic criteria Gamma-glutamylcysteine synthetase deficiency is a very rare autosomal recessive disease characterized by hemolytic anemia, and, in some cases, by neurological symptoms