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Melatonin protects bloodbrain barrier integrity and permeability by inhibiting matrix metalloproteinase-9 via the NOTCH3/NF-kappaB pathway

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The dual GLP-1 receptor/glucagon receptor agonist may be, e.g., any one of the compounds referred to in WO 2015/185640, WO 2015/086733 or WO 2015/155139, which are incorporated herein by reference