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The inflammation-modulatory effects of hBMSC treatment included a significant increase in the gene expression of IL-10 and its receptor in ovarian tissues, elevated serum levels of IL-10, IFN-, and tissue inhibitor of metalloproteinase-2, and a decrease in the gene expression of pro-inflammatory markers such as IL-6, IL-1, CCL2, and CD11c in the adipose tissue of PCOS mice [135]

Cunningham JT, Mifflin SW, Gould GG, Frazer A (2008) Induction of c-Fos and deltaFosB immunoreactivity in rat brain by vagal nerve stimulation

Originally, it was considered that growth in ROS production leads to S-glutathionylation to prevent irreversible oxidation of protein cysteine residues and disturbance of protein functions [34]

Oxidative stress is a key driver of premature aging, damaging cells and accelerating the breakdown of skin structure and body tissues